Nuclear Receptor Corepressor 2 (NCOR2)

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions.

NCOR2/SMRT is a transcriptional coregulatory protein which contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor interacting domains. NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.