Nucleosome Assembly Protein 1 Like Protein 1 (NAP1L1)

NAP1L1encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing of this gene results in several transcript variants; however, not all have been fully described.

The deduced amino acid sequence of the identified protein, designated NRP (for 'NAP-related protein'), has a potential 7-residue nuclear localization motif, 3 clusters of highly acidic residues, and other structural features found in various proteins implicated in chromatin formation. NRP transcript was detected in all human tissues and cell lines studied, but levels were somewhat increased in rapidly proliferating cells.