Ocular Choroid Fibroblasts (OCF)

The choroid, also known as the choroidea or choroid coat, is the vascular layer of the eye, containing connective tissue, and lying between the retina and the sclera. It contains a wealth of blood vessels and pigment cells, is the posterior part of the eye membrane, by the fiber tissue, small blood vessels and capillaries, continued to connect to the rear of the ciliary body.

Fibroblasts are mesenchymal cells which perform many vital functions during development and in adulthood. They are responsible for much of the synthesis of extracellular matrix in connective tissue and play major roles in wound healing. Many diseases are associated with fibroblasts, either because fibroblasts are implicated in their etiology or because of the fibrosis that accompanies damage to other cell types. Fibroblasts are one of the most accessible mammalian cell types and one of the easiest types of cells to grow in culture. Ocular Choroid fibroblasts (OCF) may be involved in the formation of the final scar of the retina, and penetrate the Bruchs membrane to enter the retina, forming the choroidal neovascularization.