Oxoguanine Glycosylase 1 (OGG1)
HMMH; HOGG1; MUTM; OGH1; 8-Oxoguanine DNA Glycosylase; DNA-(apurinic or apyrimidinic site) lyase; N-glycosylase/DNA lyase
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OGG1 is the primary enzyme responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen species (ROS). The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targeting signal, essential for mitochondrial localization.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC704Hu01 Recombinant Oxoguanine Glycosylase 1 (OGG1) In Stock
- Active protein APC704Hu01 Active Oxoguanine Glycosylase 1 (OGG1) In Stock
- Polyclonal antibody PAC704Hu01 Polyclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) In Stock
- Monoclonal antibody MAC704Hu22 Monoclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) In Stock
- Sandwich ELISA SEC704Hu ELISA Kit for Oxoguanine Glycosylase 1 (OGG1) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPC704Mu01 Recombinant Oxoguanine Glycosylase 1 (OGG1) In Stock
- Recombinant protein RPC704Mu02 Recombinant Oxoguanine Glycosylase 1 (OGG1) In Stock
- Polyclonal antibody PAC704Mu01 Polyclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) In Stock
- Polyclonal antibody PAC704Mu02 Polyclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) In Stock
- Sandwich ELISA SEC704Mu ELISA Kit for Oxoguanine Glycosylase 1 (OGG1) In Stock
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Oxoguanine Glycosylase 1 (OGG1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Oxoguanine Glycosylase 1 (OGG1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Oxoguanine Glycosylase 1 (OGG1) ELISA Kit Customized Service Offer