Bromodomain And PHD Finger Containing Protein 1 (BRPF1)

BRPF1 is expressed ubiquitously and at the highest level in testes and spermatogonia. The protein is localized within nuclei, and it is very similar in structure to two zinc finger proteins, AF10 and AF17. It is suggested that these proteins form a family of regulatory proteins. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.BR140 is very similar in structure to 2 other zinc finger genes, AF10 and AF17 (MLLT6), and suggested that they form a family of regulatory proteins.BR140 migrates as a 150-kD protein on SDS-PAGE. Northern blots showed that BR140 is expressed ubiquitously. Western blots and immunohistochemistry revealed that BR140 is expressed at the highest level in testes and spermatogonia, and is localized within nuclei.