Peritoneal Mesothelial Cells (PMC)

Peritoneal mesothelial cells (PMCs) is a thin layer of cells that cover the surface of the peritoneal cavity and are the first line of cells in contact with aggressive tumors. these serve as the primary barrier of the abdominal cavity. Thus, PMCs play a central role in the progression of peritoneal tumors.Damage to peritoneal mesothelial cells (PMCs) is believed to cause peritoneal adhesion (PA) by promoting inflammation, fibrin deposition, and fibrosis formation. Researches demonstrated that the epithelial phenotype of PMCs exhibits an inhibitory effect on abdominal cavity metastasis, whereas the mesenchymal phenotype of PMCs significantly promotes the progression of abdominal cavity tumors.