Peroxisome Proliferator Activated Receptor Delta (PPARd)

Peroxisome proliferator-activated receptor delta is a  member of the peroxisome proliferator-activated receptor (PPAR) family. It was first identified in Xenopus in 1993.PPAR-delta/beta；is the main target of a chemical substance named GW 501516. Using this ligand as a research ligand, It has been shown that agonism of PPAR-delta changes the body's fuel preference from glucose to lipids. PPAR-delta/beta is highly expressed in colon, small intestine, liver and keratinocytes. In contrast, heart, spleen, skeletal muscle, lung, brain and thymus show low expression.

Knockout mice lacking the ligand binding domain of PPAR-delta/beta are viable. However these mice are smaller than the wild type both neo and postnatally. In addition, fat stores in the gonads of the mutants are smaller.