Phosphodiesterase 10A (PDE10A)

Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.

The deduced 779-amino acid protein has a calculated molecular mass of 88.4 kD and contains cGMP-binding sequences and a catalytic domain. Northern blot analysis detected a 10-kb PDE10A transcript in several tissues, with highest levels in fetal brain and kidney, in putamen and caudate nucleus of adult brain, and in thyroid and testis. A 4-kb transcript was also detected in thyroid and testis. mRNA dot blot analysis showed a similar PDE10A expression pattern.