Phosphoenolpyruvate Carboxykinase 1, Soluble (PCK1)

Phosphoenolpyruvate carboxykinase is an enzyme used in the natural process of gluconeogenesis. It converts oxaloacetate into phosphoenolpyruvate and carbon dioxide.

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.