Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE)
PIP5K3; CFD; PIP5K; PIKfyve; p235; Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase,Type III; 1-phosphatidylinositol 3-phosphate 5-kinase
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PIKFYVE make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Recombinant Protein Customized Service Offer
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- Sandwich ELISA SEL531Hu ELISA Kit for Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPL531Mu01 Recombinant Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) In Stock
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- Customized Service n/a CLIA Kit for Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) ELISA Kit Customized Service Offer