Phosphoinositide Dependent Protein Kinase 1 (PDPK1)
PDK1; PkB-Like 1
PDPK1 is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signalling pathways activated by several growth factors and hormones including insulin signalling. Mice lacking PDPK1 die during early embryonic development, indicating that this enzyme is critical for transmitting the growth-promoting signals nescessary for normal mammalian development.
Mice that are deficient in PDPK1 have a asymp 40% decrease in body mass, mild glucose intolerance, and are resitant to cancer brought about by hyperactivation of the PI3K pathway (PTEN +/-).The structure of PDPK1 can be divided into two domains; the kinase or catalytic domain and the PH domain.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC246Hu01 Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1) In Stock
- Polyclonal antibody PAC246Hu01 Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1) In Stock
- Customized Service n/a CLIA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Recombinant protein RPC246Mu01 Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1) In Stock
- Recombinant protein RPC246Mu02 Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1) In Stock
- Polyclonal antibody PAC246Mu01 Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1) In Stock
- Polyclonal antibody PAC246Mu02 Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1) In Stock
- Sandwich ELISA SEC246Mu ELISA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1) In Stock
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1) ELISA Kit Customized Service Offer