Platelet Derived Growth Factor AA (PDGFAA)
PDGF-AA
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The receptor for PDGF, PDGFR is classified as a receptor tyrosine kinase (RTK), a type of cell surface receptor. Two types of PDGFRs have been identified: alpha type and beta type PDGFRs. The alpha type binds to PDGF-AA, PDGF-BB and PDGF-AB while the beta type PDGFR binds with high affinity to PDGF-BB and PDGF-AB. PDGF binds to PDGFRs ligand binding pocket located within the second and third immunoglobulin domains. Upon activation by PDGF, these receptors dimerise, and are "switched on" by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway. The role of PI3K has been investigated by several laboratories. Accumulating data suggests that while this molecule is generally part of growth signaling complex, it plays a more profound role in controlling cell migration.
Organism species: Homo sapiens (Human)
- Recombinant protein RPA523Hu01 Recombinant Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Active protein APA523Hu01 Active Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Polyclonal antibody PAA523Hu01 Polyclonal Antibody to Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Labelled antibody LAA523Hu71 Biotin-Linked Polyclonal Antibody to Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Labelled antibody LAA523Hu81 FITC-Linked Polyclonal Antibody to Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Monoclonal antibody MAA523Hu21 Monoclonal Antibody to Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Labelled antibody LAA523Hu72 Biotin-Linked Monoclonal Antibody to Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Monoclonal antibody MAA523Hu22 Monoclonal Antibody to Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Sandwich ELISA SEA523Hu ELISA Kit for Platelet Derived Growth Factor AA (PDGFAA) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPA523Mu01 Recombinant Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Polyclonal antibody PAA523Mu01 Polyclonal Antibody to Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Sandwich ELISA SEA523Mu ELISA Kit for Platelet Derived Growth Factor AA (PDGFAA) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPA523Ra01 Recombinant Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Polyclonal antibody PAA523Ra01 Polyclonal Antibody to Platelet Derived Growth Factor AA (PDGFAA) In Stock
- Customized Service n/a CLIA Kit for Platelet Derived Growth Factor AA (PDGFAA) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Platelet Derived Growth Factor AA (PDGFAA) ELISA Kit Customized Service Offer