Pleckstrin Homology Domain Containing Family H, Member 1 (PLEKHH1)

Pleckstrin Homology Domain Containing Family H, Member 1 (PLEKHH1)
PLEKKH1 contain pleckstrin (PLEK) homology (PH), myth4, and band 4.1 domains. Pleckstrin homology domain (PH domain) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
This domain can bind Phosphatidylinositol lipids within biological membranes (such as Phosphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate), and proteins such as the beta/gamma-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)