Polyribonucleotide Nucleotidyltransferase 1 (PNPT1)

PNPT1 is a subunit of the exosome complex, which is involved in 3-prime-to-5-prime exoribonuclease activity for RNA processing and degradation.

The variants differ only in the length of their 3-prime UTRs, and both encode a deduced 783-amino acid protein with a calculated molecular mass of 86 kD. PNPT1 contains 2 RNase PH domains, a KH domain, and a C-terminal S1 domain. Northern blot analysis detected 4.0- and 2.6-kb transcripts in terminally differentiated human melanoma cells.Expression of PNPT1 was induced by interferon-beta in a human metastatic melanoma cell line, and expression of PNPT1 suppressed melanoma cell colony formation.