Subcutaneous Preadipocytes (SPrAD)

Adipocytes play an important role in energy storage and metabolism. Adipocyte differentiation plays an important role in energy storage and metabolism. Adipocyte differentiation is a developmental process that is critical for metabolic homeostasis and nutrient signaling. It is controlled by complex actions involving gene expression and signal transduction.Preadipose cells exist in adult adipose tissue and can proliferate and differentiate into mature fat cells, which promote the increase of adipose tissue.

In vitro studies have shown that different tissue-derived cells show different lipid accumulation, the expression of the transcription factor of adipose cells, and the process of apoptosis induced by TNFα. There is also a close relationship between adipocyte differentiation and many physiological and pathological processes including fat metabolism, obesity, diabetes, hyperlipidemia, and breast cancer. Subcutaneous preadipocytes are isolated from subcutaneous fat tissue.