Proinsulin (PI)
INS; Pro-Insulin; Preproinsulin
Proinsulin is synthesized in the pancreatic beta cells as a 9390 mw polypeptide of 86 amino acids. Proinsulin is subsequently cleaved enzymatically, releasing insulin into the circulation along with a residual 3000 mw fragment called C-peptide, so-named because it connects the A and B chains of insulin within the proinsulin molecule.
Proinsulin, which has relatively low biological activity (approximately 10% of insulin potency), is the major storage form of insulin. Normally, only small amounts (~3% of the amount of insulin, on a molar basis) of proinsulin enter the circulation. Because the hepatic clearance of proinsulin is only 25% of insulin clearance, the half-life of proinsulin is two- to threefold longer and concentrations in the fasting state are approximately 10% to 15% of insulin concentrations.
Organism species: Homo sapiens (Human)
- Recombinant protein RPA379Hu01 Recombinant Proinsulin (PI) In Stock
- Customized Service n/a Monoclonal Antibody to Proinsulin (PI) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Proinsulin (PI) Polyclonal Antibody Customized Service Offer
- Competition ELISA CEA379Hu ELISA Kit for Proinsulin (PI) In Stock