Proline Rich Protein 13 (PRR13)

Taxanes, such as taxol and docetaxel, are a family of chemotherapeutic agents that have antineoplastic effects against a wide range of cancers. By screening retrovirus-infected prostate cancer cell lines for clones showing taxol resistance, followed by PCR-based genomic walking and database analysis, Lih et al. (2006) identified 3 splice variants of PRR13, which they called TXR1. Two variants differ only in their 5-prime UTRs and encode a 148-amino acid protein with a calculated molecular mass of 15.2 kD. The third variant has a 5-prime deletion and encodes a protein lacking the first 56 amino acids. The full-length TXR1 protein has a proline-rich N terminus and a histidine- and lysine-rich C terminus that also contains a continuous stretch of 10 serines. Secondary structure analysis revealed several putative N-terminal alpha helices and C-terminal beta-sheet structures.