Prostaglandin E Receptor 1 (EP1)

) is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2).

Through a phosphatidylinositol-calcium second messenger system, G_q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.