Proteasome Activator Subunit 2 (PSME2)
PA28B; PA28beta; REGbeta; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; Proteasome activator 28 subunit beta
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Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits of the 11S regulator have been identified.
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PSME2 encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a Polyclonal Antibody to Proteasome Activator Subunit 2 (PSME2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Proteasome Activator Subunit 2 (PSME2) CLIA Kit Customized Service Offer
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