Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ)

PTPRQ belongs to the type III receptor-like protein-tyrosine phosphatase (PTPase) family. PTPRQ has low activity against phosphotyrosine, but is active against phosphatidylinositol phosphates that are involved in regulation of survival, proliferation, and subcellular architecture. The genomic region containing nt 391..910 of this sequence are inverted in the human reference genome (build 37). This portion of the RefSeq is inferred based on alignments of rat and mouse transcripts, and is supported by the human Celera assembly.
In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.