Protein Tyrosine Phosphatase Receptor Type O (PTPRO)

Receptor-type tyrosine-protein phosphatase O is tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. 

It is a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif.

The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.

The human GLEPP1 gene predicts a protein of 1,188 amino acids. The 1,159-amino acid predicted mature protein contains a large extracellular domain, a single transmembrane domain, and a single intracellular PTPase domain.