Protocadherin Alpha 10 (PCDHa10)

CNR8; CRNR8; CNRN8; CNRS8

Protocadherin Alpha 10 (PCDHa10)
PCDHA10 is 1 of 15 tandemly arranged genes within the PCDHA gene cluster on chromosome 5q31. The 15 PCDHA genes function as 'variable' exons that are individually spliced to a downstream constant region to form distinct PCDHA transcripts. These transcripts encode cadherin-like cell surface proteins that are expressed in neurons and are present at synaptic junctions.
Noonan et al. (2003) identified a 16.7-kb deletion within the PCDHA gene cluster that truncated the PCDHA8 gene and completely removed the PCDHA9 and PCDHA10 genes. This deletion appeared in 'normal' individuals from multiple populations, suggesting that a reduction in protocadherin gene number is not obviously deleterious

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)