Protocadherin Gamma A3 (PCDHgA3)

PCDHGA3 is 1 of 22 tandemly arranged genes within the PCDHG gene cluster on chromosome 5q31. The 22 PCDHG genes function as 'variable' exons that are individually spliced to a downstream constant region to form distinct PCDHG transcripts. The variable PCDHG exons encode the extracellular and transmembrane domains of the protocadherin protein, and the common region encodes the intracellular domain. For further information on the PCDHG genes.Sequence analysis predicted that the long isoform of PCDHGA3 contains 932 amino acids and is 48% identical to PCDHGC4. The C-terminal 134 amino acids of PCDHGA3 and PCDHGC4 are identical and have a lysine-rich motif. PCDHGA3 has a signal peptide, 4 putative N-linked glycosylation sites, and 6 cadherin ectodomains.