Pulmonary Microvascular Endothelial Cells (PMEC)

Pulmonary microvascular endothelial cells (PMEC) cover the surface of micro blood vessel, which is not only an important barrier for the exchange of internal and external substances, but also an important target for the role of risk factors in circulation. Many pathogenic factors such as inflammation, hypoxia, oxidative stress, endotoxin can stimulate the secretion of cytokines, which play an important role in vascular disease. PMEC plays an important role in physiological and pathological conditions, such as adult respiratory distress syndrome, pulmonary hypertension, etc.. It is limited to the study of pulmonary artery endothelial cells, while there is a significant difference in the phenotype and function between pulmonary microvascular and large vessels. Therefore, it is necessary to develop and study pulmonary microvascular endothelial cells.