Purinergic Receptor P2X, Ligand Gated Ion Channel 5 (P2RX5)

P2X purinoceptor 5 is a protein belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene.

The predicted 422-amino acid human P2X5R protein shares 62% identity with rat P2X5, but has only 1 of the 2 transmembrane domains found in other P2X receptor subunits. In vitro translation of the human P2X5R cDNA produced a protein that migrated at 49 kD by SDS-PAGE.