Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12)

In the field of molecular biology, the P2Y₁₂ protein is found on the surface of blood platelet cells and is an important regulator in blood clotting.

P2RY12belongs to a group of G protein-coupled purinergic receptors and is a chemoreceptor for adenosine diphosphate (ADP). The P2Y family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.