Purinergic Receptor P2Y, G Protein Coupled 2 (P2RY2)

P2Y purinoceptor 2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.

Expression of P2RY2 in 1321N1 cells revealed evidence for autocrine ATP release and stimulation of transduced receptors. Thus, P2RY2 expression in the cell line was proposed as a useful system for studying autocrine regulatory mechanisms and for screening potential therapeutic drugs.