Ras Related C3 Botulinum Toxin Substrate 3 (Rac3)

RAC3 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.

RAC3 shares 92% and 89% amino acid identity, respectively, with RAC1 and RAC2 but differs from RAC1 and RAC2 at its C-terminal end, a domain associated with subcellular localization and binding to specific cellular regulators. RAC3 mRNA expression patterns differed from those of RAC2, which is hematopoietic cell-specific, and also from those of RAC1.Morris et al. (2000) determined the genomic structure of the RAC3 gene. The gene contains 6 exons.