Regulating Synaptic Membrane Exocytosis 2 (RIMS2)

RIMS2 gene contains 32 exons and spans 747.9 kb. In addition to the 5-prime promoter region, RIMS2 has 2 internal promoters within GC-rich regions that are used for expression of RIM2-beta and RIM2-gamma.The deduced 1,188-amino acid protein was predicted to be related to RIM1 and to be involved in cell signaling/communication. RT-PCR analysis detected high expression of KIAA0751 in brain, with lower expression in ovary and testis.

rat Rim2 interacted with Rab3a and Rab3c in a GTP-dependent manner. Yeast 2-hybrid analysis of a rat brain cDNA library revealed that the C-terminal half of rat Rim2 interacted with Rimbp1 (BZRAP1) and Rimbp2 .