Ret Finger Protein Like Protein 2 (RFPL2)

RNF79; RING finger protein 79

Ret Finger Protein Like Protein 2 (RFPL2)
The deduced 288-amino acid RFPL2 protein is 91 to 94% identical to RFPL1 and RFPL3. Exon 1 of RFPL2 encodes a putative RING-like motif, and exon 2 encodes a B30-2 domain. Northern blot analysis revealed expression of a 1.5-kb transcript that was abundant in prostate and less abundant in adult brain, fetal liver, and fetal kidney. A 1.2-kb transcript strongly expressed in testis and a 6-kb transcript strongly expressed in adult and fetal brain appeared to represent RFPL3S and RFPL1S, respectively.
The human RFPL1, RFPL2, and RFPL3 genes are transactivated by the corticogenic transcription factor PAX6. Real-time PCR demonstrated that RFPL1,2,3 are highly expressed in embryonic stem cell-derived neurogenesis and in fetal neocortex.

Organism species: Homo sapiens (Human)