Retinal Pigment Epithelium Specific Protein 65kDa (RPE65)
LCA2; RP20; mRPE65; rd12; sRPE65; Retinoid isomerohydrolase; All-trans-retinyl-palmitate hydrolase; Retinol isomerase
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65 is a protein which is located in the retinal pigment epithelium and is involved in the conversion of all-trans retinol to 11-cis retinal during phototransduction, which is then used in visual pigment regeneration in photoreceptor cells. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Recombinant protein RPC768Mu01 Recombinant Retinal Pigment Epithelium Specific Protein 65kDa (RPE65) In Stock
- Customized Service n/a Monoclonal Antibody to Retinal Pigment Epithelium Specific Protein 65kDa (RPE65) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Retinal Pigment Epithelium Specific Protein 65kDa (RPE65) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Retinal Pigment Epithelium Specific Protein 65kDa (RPE65) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Retinal Pigment Epithelium Specific Protein 65kDa (RPE65) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Retinal Pigment Epithelium Specific Protein 65kDa (RPE65) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Retinal Pigment Epithelium Specific Protein 65kDa (RPE65) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Retinal Pigment Epithelium Specific Protein 65kDa (RPE65) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Retinal Pigment Epithelium Specific Protein 65kDa (RPE65) ELISA Kit Customized Service Offer