Retinitis Pigmentosa 1 Like Protein 1 (RP1L1)

The deduced 2,464-amino acid protein contains 2 N-terminal doublecortin (DC) domains, 2 imperfect repeats of a 16-amino acid module, and 2 C-terminal coiled-coil domains.

RP1L1 shares 39% amino acid identity with mouse Rp1l1, with highest identity in the N-terminal region. Mouse Rp1l1 does not contain the coiled-coil domain or the 2 repeats found in human RP1L1. RP1L1 also shares significant similarity in the N-terminal DC domains with RP1. Semiquantitative RT-PCR showed RP1L1 expression only in retina. Northern blot analysis of adult mouse tissues detected 2 weak bands of about 7.5 and 5.0 kb only in retina. EST database analysis detected RP1L1 sequences only in retina and eye cDNA libraries.RP1L1 gene contains 4 exons and spans 52 kb.