Runt Related Transcription Factor 1 Translocated To 1 (RUNX1T1)

RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The encoded truncated proteins lack 177 C-terminal residues, which is the region containing 2 putative zinc finger motifs, the last P/S/T-rich domain, and a putative alpha-helical coiled-coil structure. Northern blot analysis of human tissues detected an approximately 5.5-kb MTG8 transcript in heart, brain, placenta, lung, skeletal muscle, and pancreas but not in liver or kidney. Relatively abundant mRNA levels were also found in lung, pituitary, and placenta.