Zinc Finger Homeobox Protein 1B (ZFHX1B)

The ZEB2 gene is a member of the ZEB1/Drosophila Zfh1 family of 2-handed zinc finger/homeodomain proteins and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs , the transducers of TGF-beta signaling, and interacts with the nucleosome remodeling and histone deacetylation (NURD) complex.

The Smadip1 protein contains a SMAD-binding domain, a homeodomain-like sequence, and 2 separate clusters of zinc fingers, one N-terminal and the other C-terminal.The deduced 1,214-amino acid protein shares significant similarity with rat Zeb1. RT-PCR analysis of human tissues detected highest ZEB2 expression in heart, brain, lung, placenta, and kidney, with moderate expression in ovary, skeletal muscle, liver, and small intestine.