SNF Related Kinase (SNRK)

SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases. The deduced protein has a prenylation site. Northern blot analysis detected SNRK expression in all tissues and cell lines examined, with highest expression in peripheral blood leukocytes.

The deduced 766-amino acid protein has a calculated molecular mass of 84.27 kD and shares 88% identity with mouse Snrk. Human, rat, and mouse SNRK proteins share a conserved serine/threonine kinase catalytic domain, a bipartite nuclear targeting signal, and an SNF1 homology domain (SNH), the latter being characteristic of some SNF1-related proteins and also found within a ubiquitin-associated (UBA) domain in ubiquitin pathway enzymes.