Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3)
SPTLC2L; SPT 3; LCB 3; C20orf38; Aminotransferase 2; Serine-palmitoyl-CoA transferase 3; Long chain base biosynthesis protein 3
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SPTLC3 orthologs were found in rat, mouse, and dog. Quantitative real-time PCR of human tissues showed highest expression in placenta, followed by skin, adrenal gland, testis, uterus, salivary gland, prostate, and kidney, lower expression in all other tissues, and no expression in peripheral blood cells and bone marrow. SPTLC3 and SPTLC2 showed different expression patterns, possibly reflecting tissue-specific requirements of sphingolipid synthesis. Western blot analysis revealed SPTLC3 expression in human trophoblast cell lines. Overexpression of SPTLC3 in HEK293 cells, which have little endogenous SPTLC3, resulted in increased SPT activity by 2- to 3-fold. Expression of an SPTLC3-specific siRNA in HepG2 cells and human trophoblast cells significantly decreased SPT activity, indicating that SPTLC3 plays a role in SPT activity.
Organism species: Homo sapiens (Human)
- Recombinant protein RPH136Hu01 Recombinant Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) In Stock
- Monoclonal antibody MAH136Hu21 Monoclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) In Stock
- Polyclonal antibody PAH136Hu01 Polyclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) In Stock
- Sandwich ELISA SEH136Hu ELISA Kit for Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPH136Mu01 Recombinant Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) In Stock
- Recombinant protein RPH136Mu02 Recombinant Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) In Stock
- Polyclonal antibody PAH136Mu01 Polyclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) In Stock
- Polyclonal antibody PAH136Mu02 Polyclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) In Stock
- Sandwich ELISA SEH136Mu ELISA Kit for Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) In Stock
Organism species: Rattus norvegicus (Rat)
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