Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3)

Lehmeier et al. (1994) obtained partial amino acid sequence for the D2 and D3 protein components of small nuclear ribonucleoproteins (snRNPs). Degenerate oligomers were designed and used to isolate 2 cDNAs from a HeLa cell library. The sequence of the D3 cDNA predicts a 126-amino acid protein with 29% identity to the D1 polypeptide. Recombinantly expressed protein could be precipitated with anti-Sm antibodies.

Small nuclear ribonucleoprotein Sm D3 is a protein that belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. SNRPD3 has been shown to interact with DDX20, CLNS1A, CDC5L and Protein arginine methyltransferase 5.