Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE)

SNRPE is 1 of 4 'core' proteins associated with all known snRNAs in the U family.The gene for the E protein is 9 kb long and contains 5 exons. The sequence is known for 9 closely related genes that have several features of processed pseudogenes. The longest open reading frame coded for a basic 92-amino acid protein which had an amino acid sequence in perfect agreement with that obtained from purified E protein.At least one of the SNRPE pseudogenes is linked to a signal transduction G protein gene that also maps to chromosome 1. Two other small nuclear ribonucleoprotein (snRNP) components--the U1 RNA 'true' multigene family and a group of class I U1 pseudogenes--are located on chromosome 1.