Solute Carrier Family 25, Member 24 (SLC25A24)

The calcium-binding domain shares 25% identity with calmodulin , with 4 EF-hand motifs at conserved positions. SCAMC1 also shares significant similarity with SCAMC2 (SLC25A25) and SCAMC3 (SLC25A23), with most differences in the N termini and EF-hand 1.

Northern blot analysis detected a 3.4-kb SCAMC1 transcript in all tissues examined, and expression of SCAMC1 was generally higher than that of SCAMC2 or SCAMC3. Both endogenous and transfected epitope-tagged SCAMC1 were expressed in a subcellular pattern that overlapped with a mitochondrial marker. Western blot analysis of mitochondria-enriched fractions of a number of cell lines showed that SCAMC1 migrated at an apparent molecular mass of 48 to 50 kD.