Sorting Nexin 17 (SNX17)

Sorting nexin-17 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain.

This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.the deduced 470-amino acid SNX17 protein contains a PX domain that shares 28% sequence identity with the PX domain of sorting nexin-1 as well as a B41 (FERM) domain. Expression of a GFP-SNX17 fusion protein demonstrated localization of SNX17 in the cytosol and on membranes.