Sorting Nexin Associated Golgi Protein 1 (SNAG1)

Sorting nexins are a large group of proteins with the common characteristic of having a PX domain (a phospholipid-binding motif). Some members of this family have been shown to facilitate protein sorting.Sorting nexins either consist solely of a PX domain (eg SNX3) or have a modular structure made up of the PX and additional domains.

Sorting nexin-18 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. The specific function of this protein has not been determined.