Sperm Adhesion Molecule 1 (SPAM1)
HYAL1; HYA1; HYAL3; HYAL5; PH-20; PH20; SPAG15; PH-20 Hyaluronidase; Zona Pellucida Binding
SPAM1was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple protein isoforms are encoded by transcript variants of this gene.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC866Hu01 Recombinant Sperm Adhesion Molecule 1 (SPAM1) In Stock
- Polyclonal antibody PAC866Hu01 Polyclonal Antibody to Sperm Adhesion Molecule 1 (SPAM1) In Stock
- Sandwich ELISA SEC866Hu ELISA Kit for Sperm Adhesion Molecule 1 (SPAM1) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPC866Mu01 Recombinant Sperm Adhesion Molecule 1 (SPAM1) In Stock
- Polyclonal antibody PAC866Mu01 Polyclonal Antibody to Sperm Adhesion Molecule 1 (SPAM1) In Stock
- Sandwich ELISA SEC866Mu ELISA Kit for Sperm Adhesion Molecule 1 (SPAM1) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPC866Ra01 Recombinant Sperm Adhesion Molecule 1 (SPAM1) In Stock
- Customized Service n/a Monoclonal Antibody to Sperm Adhesion Molecule 1 (SPAM1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Sperm Adhesion Molecule 1 (SPAM1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Sperm Adhesion Molecule 1 (SPAM1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Sperm Adhesion Molecule 1 (SPAM1) ELISA Kit Customized Service Offer