Splenic Mononuclear Cells (SpMC)

Splenic mononuclear cells (SMCs) are a group of immune-functional cells present in the spleen, playing a crucial role in the body's immune response. These cells include various subtypes, such as T cells, B cells, natural killer (NK) cells, monocytes, macrophages, and dendritic cells (DCs). These cells play critical roles in adaptive and innate immune responses, including antigen presentation, cytokine production, and antibody synthesis. Splenic MCs are typically isolated via density gradient centrifugation (e.g., using Ficoll-Paque® or Percoll®), which separates them from granulocytes and erythrocytes.