Suppressor Of Ty 5 Homolog (SUPT5H)

The yeast suppressor of Ty (SPT) genes were isolated based on their ability to suppress insertion of the Ty phage. These genes encode a variety of proteins that are involved in chromosome activity, including histones and transcription factors. The SPT genes are not necessarily homologs of one another. SPT4, SPT5, and SPT6 are believed to be parts of a protein complex involved in transcriptional repression by modulating chromatin structure.

The N terminus of SUPT5H is highly acidic, while the C terminus contains 7 mitogen-activated protein (MAP) kinase consensus sequences.the SUPT5H sequence contains a putative nuclear localization signal. SUPT5H was expressed as a 4-kb transcript at varying levels in every adult human tissue tested.