TEA Domain Family, Member 1 (TEAD1)

TEAD1 a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Additional transcript variants have been described but their full-length natures have not been experimentally verified.

The enhancer of simian virus 40 (SV40) is a cis-acting regulatory element that stimulates transcription from RNA polymerase B(II) promoters. Genetic studies have demonstrated that this enhancer consists of multiple enhansons, GT-IIC, GT-I, TC-II, Sph-II, Sph-I, octamer, and P, which function synergistically in a cell-specific manner. In vitro binding studies have identified several proteins, some of which exhibit cell-specific activity, interacting with these SV40 enhansons.