Tachykinin Receptor 3 (TACR3)

Tachykinin receptor 3, also known as TACR3, is a protein belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.

Huang et al. (1992) isolated cDNA clones encoding the human neurokinin-3 receptor from human brain mRNA. The cloned neurokinin-3 receptor was expressed in COS cells and Xenopus oocytes, where peptide binding affinity and intracellular effector activation were determined. Neurokinin B was the most potent agonist.