Tau-Tubulin Kinase 2 (tTBK2)
SCA11; Spinocerebellar Ataxia 11
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TTBK2 produces a 5.6-kb transcript in which the longest open reading frame is 3,732 nucleotides, encoding a protein of 1,244 amino acids. The gene is alternatively spliced, with ubiquitous expression in human adult and fetal tissues. The N-terminus of TTBK2 encodes a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK2 was expressed in all brain regions in human, rat, and mouse tissue. There was particularly high expression in Purkinje cells of the cerebellum, granular cell layer, hippocampus, midbrain, and substantia nigra. Lower expression was seen in the cortex of human, rat, and mouse brains.2 TTBK2 phosphorylation sites in tau (ser208 and ser210) are priming sites for the phosphorylation of tau by GSK-3-beta, which influences tau pathology.
Organism species: Homo sapiens (Human)
- Recombinant protein RPE723Hu01 Recombinant Tau-Tubulin Kinase 2 (tTBK2) In Stock
- Monoclonal antibody MAE723Hu21 Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) In Stock
- Polyclonal antibody PAE723Hu01 Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) In Stock
- Sandwich ELISA SEE723Hu ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) In Stock
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Tau-Tubulin Kinase 2 (tTBK2) Recombinant Protein Customized Service Offer
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- Sandwich ELISA SEE723Mu ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) In Stock
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Tau-Tubulin Kinase 2 (tTBK2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) Polyclonal Antibody Customized Service Offer
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