Threonyl tRNA Synthetase (TARS)

Aminoacyl tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution.

Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family.Of the 7 aminoacyl-tRNA synthetase genes mapped to that time, 4 were known to be on chromosome 5, which represents only about 7% of the total human genome. By study of human-hamster cell hybrids, TARS is very closely linked to LARS; the latter is located at 5pter-q11 .