Transcriptional Intermediary Factor 1 Gamma (TIF1g)

TIF1gis thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified. Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors.

The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains:RING; B-box type 1 zinc finger; B-box type 2 zinc finger; and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.