Transglutaminase 7 (TGM7)

TGMZ; TGZ; Transglutaminase Z; Protein-glutamine gamma-glutamyltransferase Z

Transglutaminase 7 (TGM7)
Transglutaminases (TGM; EC are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks.
Grenard et al. (2001) cloned a novel TGM cDNA, designated TGM7, by RT-PCR and anchored PCR of human prostate carcinoma tissues and cells, using degenerate primers based on the conserved active site sequence. The deduced 710-amino acid protein has a calculated molecular mass of about 80 kD. TGM7 contains a conserved cys-his-asp catalytic triad and a calcium-binding domain. Its core domain shares 50% sequence identity with other TGMs. Northern dot blot analysis detected ubiquitous low level expression of TGM7, with highest levels in testis and lung.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)